Abstract: Clinicopathologic Features of Uterine Tumors Resembling Ovarian Sex Cord TumorsYihua CHEN1, Yi JIAN1, Zhiling YANG2, Yanyan FAN1, Yan LUO1Correspondence to: Yihua CHEN, E-mail: chenyihua0520@sina.com1Department of Pathology, General Hospital of Chengdu Military Command, Chengdu 610083, China2Department of Gynecology and Obstetrics, General Hospital of Chengdu Military Command, Chengdu 610083, ChinaAbstract Objective: To explore the clinicopathologic features of uterine tumor resembling ovarian sex cord tumor (UTROSCT ). Methods: Clinical data, light microscopy and immunohistochemistry results from 3 UTROSCT cases were analyzed. Im-munohistochemical staining was performed to detect calretinin, alpha-inhibin, Melan A, CD99, CK7, ER, PR, CD10, SMA, EMA, des-min, Calponin, h-caldesmon and HMB45 using the En Vision method. Results: Cords, nests, trabecular ribbons, and solid architecturewere seen. Tumor cells were small with bland nuclei and abundant eosinophilic or foamy cytoplasm, rare mitotic activity and necrosis.Immunohistochemically, tumor cells were positive for calretinin and alpha-inhibin, negative for CD10, SMA, desmin, Calponin,h-caldesmon and HMB45, and partially positive for Melan A, CD99, CK7, EMA, ER and PR. Follow-up data were available for all 3patients and none had local recurrence after treatment. Conclusion: UTROSCT is a rare neoplasm that should be considered a tumor oflow-grade malignant potential. Combined morphological and immunophenotypical analyses can be used to confirm the diagnosis. Clini-cal procedures should be performed based on the age of the patient and in consideration of the patient's plans for future children.Long-term follow-up is necessary.Keywords Uterine neoplasm; Uterine sex cord-like tumor; Immunohistochemistry; Diagnosis; Differential diagnosis